|
KMID : 0616620090150020059
|
|
Journal of Soonchunhyang Medical College
2009 Volume.15 No. 2 p.59 ~ p.69
|
|
|
Recent Concept of Guillain-Barre Syndrome
|
|
Roh Hak-Jae
Ahn Moo-Young
|
|
|
Abstract
|
|
|
~uillain-~arrs6y ndrome (GBS) is one of tho acute flaccid paralysis syndromes in human and consisting of different subtypes including acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor and sensory axonal neuropathy (AMSAN), acute sensory neuropathy, acute pandysautonomia and Fisher syndrome. The most striking feature different from other neuropathy is elevated protein level with a normal cell count in the cerebrospinal fluid known as albuminocytologic dissociation. AMAN and AMSAN may be mediated by specific anti-ganglioside antibodies that inhibit transient sodium Na’ channels, The efficacy of plasmapheresis and intravenous immunoglobulin has been established in large international randomized trials, with corticosteroids proven ineffective. Although axonal demyelination is an established pathophysiological process in GBS, the rapid improvement of clinical
deficits with treatment is consistent with Nat channel blockade by antibodies or other circulating factors, such as cytokines. This review provides an update on the epidemiology, clinical features, diagnosis, pathogenesis and treatment of GBS.
|
|
|
KEYWORD
|
|
|
Guillain-6arrb syndrome, Epidemiology, Pathophysiology, Treatment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|